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Proper nutritional, vitamin, and mineral balance in the body is critical for optimum health and the prevention of disease, something the scientific community has just recently acknowledged.  Over the years I have read many texts, books, manuals, articles, and research papers with wonderful information concerning the benefits of nutrition and the health risks of improper nutritional balance.  The unfortunate thing is that while most people think that this information is new due to the recent endorsement of nutrition by the mainstream scientific community, most of this information has been around for decades.,  The following are excerpts from some of the sources I have read throughout my educational career.  I hope that you find something of value in what I have found and continue to search for in the pursuit of knowledge.

                                                                                                                    Dr. Trent J. Burrup

The Human Body
What Is A Vitamin?
Not All Supplements Are Created Equal
Why Your Diet Isn't Enough Nutritionally
Nutritional Deficiencies Increasing Over Time
RDA - Recommended Daily Allowance
Fatty Acids
Nutritional Physiology of Muscle Twitches and Spasms
Calcium - Too Much?
Inflammation
Diet and Inflammation
Cardiovascular Disease
Cancer
Arthritis

The Human Body
Excerpts from Biomedical Critique:

  1. The human body is composed of between 80 and 100 trillion cells.

  2. Approximately1 billion cells per hour must be replaced...24 billion cells per day which require all the known elements of nutrition.

  3. A section of skin the size of a quarter (1/20 of an inch thick contains:
        a.   36 inches of blood vessels
        b.   144 inches (4 yards) of nerves
        c.   1300 nerve cells
        d.   100 sweat glands
        e.   over 3 million cells

  4. Each of the 100 trillion cells of the human body contains, in each cell, 300 to 800 power plants called mitochondria.  Each mitochondrion in liver cells contains approximately 5 thousand respiratory units.

  5. Circulating through 70,000 miles of blood vessels are 30 trillion red blood cells.  A normal, healthy human produces 15 million red blood cells per second to replace the same number that expire each second; a turnover of 900 million red blood cells per hour.  Truly amazing.

  6. The human body is composed of over 1,600 types of protein and these 1,600 types of protein are made up of different numbers of combinations on approximately 22 amino acids which are the building blocks of protein.
                Biomedical Critique, Vol. 1, No., 5, December 1980
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What Is A Vitamin?
A group of organic substances that are indispensable for the maintenance of health, normal metabolism, growth, and development of the body.  Vitamins are not sources of energy, do not contribute significantly to the substance of the body, and are effective in minute quantities.  They act principally as regulators of metabolic processes and play a role in energy transformations, usually acting as coenzymes in enzymatic systems.
                        Taber's Cyclopedic Medical Dictionary, p.2139
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Not All Supplements are Created Equal - Check the Quality of Your Vitamins
As far back as 1941, Dr. Agnes Fay Morgan, Ph.D., food research scientist at the University of California, reported in Science, 93, 261-262, that animals on a synthetic vitamin enriched diet: "Dropped dead long before the animals on an un-enriched diet became disabled."  She remarked at that time that such phony enrichment might: "Precipitate conditions worse than the original deficiency."

In his writings, Dr. Royal Lee ways that...synthetic vitamins seem to be dangerous.  Irradiated Ergo sterol (D2), the first synthetic vitamin to be widely marketed, is now known to be extremely dangerous.  It has fatally poisoned children in doses smaller than those recommended for treatment of rickets.  (JAMA, p. 1209, 4/26)

Another authority, Howard H. Hilleman, M.A., Ph.D., School of Science, Oregon State College, author of Maternal Malnutrition and Congenital Deformity  presented March 17, 1958, gave support to Dr. Lee in stating: "Excess vitamin D in the newborn and young can cause death with metastatic calcification and the synthetic forms are more dangerous than the natural forms of D."
                        Biomedical Critique, Vol. 3, No. 1, January 1982
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Why Your Diet Isn't Enough Nutritionally
(In a report to the Senate in 1936, it was found that the soils of America were depleted of the necessary nutrients to sustain life due to mass agriculture and poor crop rotation.  It is unlikely that over the years the situation has improved.  This is a portion of the Senate Report.)

During a food-science convention in Dallas, Texas, about 1958, the late William Albrecht, Ph.D., Emeritus Professor of Agronomy, Department of Soils, University of Missouri, reported then:  "Over 40 years ago, worldwide samples of soils were studied and established an average viable protein output of 12%; the minimum necessary for animal and human health being 25% viable protein.  In the United States the samples averaged not 25%, not 12%, but 6%."  During the late 1960's or early-to-mid 1970's, the U.S. Department of Agriculture released figures which indicated the average U.S. soil had a viable protein factor of 1 1/2% to 3%.

Printed in the Congressional Record, 74th Congress, 2nd Session, Senate, June 5, 1936, Senator Fletcher presented the following excerpts:

  1. "Many backward children are 'stupid' merely because they are deficient in magnesium.  We punish them for our failure to feed them properly."

  2. "Dr. Sherman of Columbia asserts that 50% of the American people are starving for calcium.  A recent article in the JAMA stated that out of 4,000 cases in a New York hospital, only 2 were not suffering from a lack of calcium (1936)".
                Biomedical Critique, Vol. 5, No. 6, September 1984
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Nutritional Deficiencies Increasing Over Time
In 1981, a report from the University of Florida revealed some startling facts.  It stated that in the year 1929, the average, young American male adult produced approximately 100 million sperm cells per milliliter of semen.  In 1973, 44 years later, the average sperm count had dropped to 60 million/ml.  Then seven years later in the 1980, the average count was down to 20 million/ml.  Incredible!
                        Biomedical Critique, Vol. 3, No. 1, January 1982
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RDA - Recommended Daily Allowance
RDA refers to "the level of intake of essential nutrients that, on the basis of scientific knowledge, are judged by the Food and Nutrition Board to be adequate to meet the known nutrient needs of practically all healthy persons" (481-p, 1).  (This is an extremely vague and unclear definition.)

Consider...the following data on nutrient intake for women.  It has been found that
            78% consume less than 100% of the RDA for calcium;
            95% consume less than 100% of the RDA for iron;
            96% consume less than 100% of the RDA for zinc;
            55% consume less than 100% of the RDA for vitamin A;
            76% consume less than 100% of the RDA for vitamin E;
            44% consume less than 100% of the RDA for vitamin C;
            94% consume less than 100% of the RDA for vitamin B6; and
            96% consume less than 100% of the RDA for folic acid (302a),
                        David R. Seaman, D.C., M.S., DABCN "Clinical Nutrition for Pain, Inflammation, and Tissue Healing
                        (p. 122-123)
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Fatty Acids
Alpha-linolenic acid is commonly found in chloroplasts of green leaves and in some plant oils including flaxseed oil and canola oil.  It is unlikely that we efficiently convert alpha-linolenic acid into EPA/DHA.  Humans have probably always depended on foods that contain preformed EPA/DHA.  Our hunter-gatherer ancestors easily obtained sufficient amounts of EPA/DHA from fat in wild game (these animals consume green plants and grasses), which contained 9% EPA.  Unfortunately, the domestic livestock that we consume today contains almost undetectable amounts of EPA.  Because domestic livestock is a main dietary staple, our current fatty acid intake pattern has been dramatically altered from that to which humans have adapted over thousands of years.  To approach the fatty acid intake pattern of our ancestors, we must obtain our EPA/DHA from fish and/or from supplements.

                         David R. Seaman, D.C., M.S., DABCN "Clinical Nutrition for Pain, Inflammation, and Tissue Healing
                        (p. 122-123)
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Nutritional Physiology of Muscle Twitches and Spasms
"The irritability of the nervous system largely depends upon a proper ratio of Na (sodium), K (potassium), and Ca (?calcium) ions; a lack of Ca or increase in K increases the irritability.

"Deprived of Mg (magnesium) for a few days...animals become highly irritable and thrown into convulsions of the slightest disturbance...Mg has an anesthetic effect on many animals.  (Balanced with ionizable Ca...Mg has a sedative or relaxant effect on humans.)

"When plasma calcium is decreased 50%, the irritability of the neuromuscular system increases so that twitching and tetany of skeletal muscles set in.  Passage of nerve impulses across the synapse or myoneural junction depends upon proper Ca."
                        Textbook of Physiology,  Zoethout and Tuttle, pg. 433-435
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Calcium -- Too much?
"The fact that we need daily calcium, and the fact that many people are low in calcium, are givens, but there are many misconceptions about how to add calcium to our diets.  Supplements can be helpful in supplying extra calcium, with the operative word being 'extra'.  It is highly important to derive the majority of our calcium from our diet, and it is wise to boost that intake with quality, highly absorbable calcium when intake is falling short of needs.  Thinking that supplements can take the place of the calcium we need from our diet can cause a problem.  For instance, 'Absorption of calcium is a little bit tricky.  If a body overdoes calcium intake, perhaps by overdosing on calcium supplements, the body will absorb less calcium from the food it eats' (The Calcium Information Center, 1997 from 'Non-Dairy: Something to Moo About, Inc.').  There appears to be good evidence that 'Too much of a good thing...' is not ideal."

"For instance:  Too much calcium, especially from a non-soluble/non-0absorbable source, can be responsible for kidney stones, bone spurs, urinary calculi, suppressed bone remodeling and mineral imbalances.,  In a study conducted in a group of men and women (aged 21-69 years), researchers measured the acute effect of a 600 mg calcium supplement on zinc absorption from a single test meal supplying 7.3 mg zinc.  Zinc absorption was reduced significantly by 50% when the calcium supplement was given with the meal (Wood RJ, Zheng JJ)."

"High dietary calcium intakes reduce zinc absorption and balance in humans.  (Am J Clin Nutr 1997 Jun;65 (6): 1803-1809.)  High intakes of calcium can inhibit iron absorption if both are present in the same meal. (Whiting SJ.  The inhibitory effect of dietary calcium on iron bioavailability: a cause for concern? Nutr Rev 1995 Mar; 53 (3): 77-80)"

"Good advice for calcium intake:  Derive the majority of calcium requirements from the diet.  There are many dietary sources of calcium, especially dark green vegetables.  Collards (one cup) contain contain 289 mg calcium, broccoli (one cup) contains 138 mg calcium, and mackerel (e ounces canned/bones) contains 263 mg calcium.  Almonds and sesame seeds also contain calcium."

"Reduce the intake of substances that deplete or offset calcium ratios, i.e. salt, soda pop, caffeine, chronic oxalate ingestion, etc."

"The average intake of calcium is around 800-900 mg. a day, and a supplement would supply up to another 400 mg or so, depending on individuality, gender, age, pregnancy, etc.  Researchers have correlated results of the nutritional surveys with results of the bone density readings and concluded that "a difference in teenage calcium intake of 400 mg/day (from 800-1200 mg) can increase adult bone density by six percent" (Nieves, J Ph.D. et.al., Helen Hayes Hospital Regional Bone Center, Havenstraw, New York - 1995)."

"Choose a high quality source of absorbable calcium, guaranteed to be free of metals, toxins, residues, etc. that has been formulated with synergistic ingredients to facilitate utilization.  Some of these ingredients include:  vitamin D, vitamin C, magnesium, and HCl."

"Upper limits: Calcium intake should not exceed 2500 mg a day, even when the calcium is derived from diet alone."
                        Dr. Lynn Toohey, Nutri West Newsletter
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Inflammation
"Inflammation is the term given to describe the biological response to what occurs as a result of tissue injury.  Microbial infections, physical agents such as trauma, chemicals (i.e. toxins and caustic substances), necrotic tissue and all types of immunologic reactions can initiate the inflammatory process (92-p. 40)."

"Without inflammation, tissue healing could not take place.  In fact, based upon the abo e description, perhaps it would be best to describe the body's response to injury as the healing process rather than the inflammatory process.  In this manner, instead of trying to treat inflammation [which implies that it is a bad process], our treatment approach would be to assist in the healing process, which mandates that we help the body to resolve the acute inflammatory reaction before it passes into a state of chronic inflammation."

"It is chronic inflammation that is always destructive to tissues and is equated with disease (92).  Based upon this information, it seems appropriate that we should view acute inflammation as part of the healing process, and that chronic inflammation should be viewed as a disease."
                        David R. Seaman, D.C., M.S., DABCN "Clinical Nutrition for Pain, Inflammation, and Tissue Healing"
                        (p. 36)
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Diet and Inflammation
"Without the initial release of the chemical mediators of inflammation, the inflammatory process would not occur and healing would not take place.  At the other end of the spectrum, if the release of the chemical mediators does not resolve, then inflammation will rage on and become chronic...the end result will be persistent nociceptor depolarization, pathological tissue fibrosis and chronic pain."

"In 1992, I suggested that the term "pro-inflammatory state" should be used to describe the general biochemical state, resulting from dietary habits that predispose the body to produce excessive chemical irritants (402).  Such a state could initiate and/or perpetuate inflammation and chronic pain.  Several factors appear to be involved.  Primarily, the problem appears to begin with a diet that contains excessive amounts of meat and desserts, and deficient qusantities of vegetables and fruits.  Over an unspecified time period, this imbalance may lead to increased tissue acidity, inadequate potassium intake, inadequate magnesium intake, free radical production, and fatty acid imbalances, all of which can promote inflammation and create a pro-inflammatory state."

                        David R. Seaman, D.C., M.S., DABCN "Clinical Nutrition for Pain, Inflammation, and Tissue Healing"
                        (p. 65)
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Cardiovascular Disease
"Over 5 years ago, Ross made it clear that atherosclerosis was driven by inflammation.  He focused on how pro-inflammatory cytokines, growth factors, free radicals and eicosanoids would be able to initiate and perpetuate atherogenesis (780).  Ross describes atherosclerosis as a disease process that is preceded and accompanied by inflammation, and in its advanced stages represents an excessive inflammatory-fibroproliferative response to many different insults (780).  For additional evidence to demonstrate that atherosclerosis is an inflammatory condition, one only needs to consider that aspirin, an anti-inflammatory drug, is used in the treatment and prevention of heart disease (773).  In fact, atherosclerotic heart disease is commonly viewed as an undesirable inflammatory response of the arteries (788)."

                        David R. Seaman, D.C., M.S., DABCN "Clinical Nutrition for Pain, Inflammation, and Tissue Healing"
                        (p. 36)
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Cancer
"Many papers have been published in recent years which explain that a fruit and vegetable-rich diet can offer protection against, and help treat, chronic diseases such as heart disease, cancer, diabetes, hypertension and other medical conditions (538, 560, 590, 652, 600, 772, 816, 838).  All of these chronic diseases are typically viewed as being inflammatory in nature.  In other words, local inflammatory processes play a significant role in promoting these diseases.  Leslie views most of these diseases as 'undesirable inflammatory responses' (700).  Heart disease and cancer are the best examples of pro-inflammatory diseases."

"It has become so common place to view heart disease and cancer as pro-inflammatory, even standard pathology books take this position.  For example, regarding the pathogenesis of stomach cancer:

 

    "Acute gastritis is an acute mucosal inflammatory process, usually transient in nature...Chronic gastritis is defined as the presence of chronic mucosal inflammatory changes leading to mucosal atrophy and epithelial metaplasia, usually in the absence of eosins.  The epithelial changes may become dysplastic and constitute a background for the development of carcinoma."  (93-p. 770-771)"

 

                        David R. Seaman, D.C., M.S., DABCN "Clinical Nutrition for Pain, Inflammation, and Tissue Healing"
                        (p. 66)
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Arthritis
"In 1991, the results of a clinical trial demonstrated that a dietary focus on vegetables and fruits could dramatically reduce inflammation and pain in patients with rheumatoid arthritis (237).  In part, the  researchers originally set out to test the utility of a vegetarian diet and then realized that many of their subjects needed to switch to a lactovegetarian diet to insure nutritional adequacy.  The study revealed that a vegetarian-based diet markedly improved all arthritis indices tested including the number of tender and swollen joints, Ritchie's articular index, pain score, duration of morning stiffness, grip strength, erythrocyte sedimentation rate, C-reactive protein, WBC count, and a health assessment questionnaire.  These benefits were present after one year (237)."

                        David R. Seaman, D.C., M.S., DABCN "Clinical Nutrition for Pain, Inflammation, and Tissue Healing"
                        (p. 65-66)
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